The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis (DMattey).pdf
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The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis.
Abstract
To investigate the influence of HLA-DRB1 alleles encoding the QK/RRAA shared epitope (SE) on radiological outcome in rheumatoid arthritis (RA), and to determine whether it is modulated by alleles carrying the putative rheumatoid arthritis-protective (RAP) sequence DERAA. Patients and methods. The association between erosive damage and HLA-DRB1 status was examined in 315 RA patients with a disease duration of 5-30 yr. Radiological outcome was measured by scoring X-rays of the hands and feet using the standard radiographs of Larsen (Larsen score). HLA-DRB1 typing was carried out using polymerase chain reaction methodology.
| Acceptance Date | Jul 1, 1999 |
|---|---|
| Publication Date | Dec 1, 1999 |
| Journal | Rheumatology (Oxford) |
| Print ISSN | 1462-0324 |
| Publisher | Oxford University Press |
| Pages | 1221 - 1227 |
| DOI | https://doi.org/10.1093/rheumatology/38.12.1221 |
| Keywords | Rheumatoid arthritis, HLA-DRB1, Shared epitope, Protective alleles, Radiological outcome |
| Publisher URL | http://rheumatology.oxfordjournals.org/content/38/12/1221.long |
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