Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom

Curtis, ADM; Malekigorji, M; Holman, J; Skidmore, M; Hoskins, C

doi:10.4172/2157-7439.1000335

Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom

Curtis, ADM; Malekigorji, M; Holman, J; Skidmore, M; Hoskins, C

Authors

Anthony Curtis a.d.m.curtis@keele.ac.uk

M Malekigorji

J Holman

Mark Skidmore m.a.skidmore@keele.ac.uk

C Hoskins

Abstract

Hybrid iron oxide-gold nanoparticles (HNPs) have shown potential in cancer therapy as agents for tumour ablation and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon resonance of the gold coating, which usually occurs at the maximum UV absorption wavelength. However, lasers at such wavelength are often expensive and highly specialised. Here, we report the heating and monitoring of heat dissipation of HNPs suspended in agar phantoms using a relatively inexpensive Ng: YAG pulsed 1064 nm laser source. The particles experience heating of up to 40°C with a total area of heat dissipation up to 132.73 mm2 from the 1 mm diameter irradiation point after 60 seconds. This work reports the potential and possible drawbacks of these particles for translation into cancer therapy based on our findings.

Acceptance Date	Nov 2, 2015
Publication Date	Nov 10, 2015
Journal	Journal of Nanomedicine and Nanotechnology
Publisher	OMICS International
Volume	6
Issue	6
DOI	https://doi.org/10.4172/2157-7439.1000335
Keywords	hybrid nanoparticles; surface plasmon resonance; heat dissipation; thermo-responsive drug delivery; laser irradiation
Publisher URL	https://doi.org/10.4172/2157-7439.1000335