Kouzouna, A, Gilchrist, FJ, Ball, VJ, Kyriacou, T, Henderson, J, Pandyan, AD and Lenney, W (2016) A systematic review of early life factors which adversely affect subsequent lung function. Paediatric Respiratory Reviews, 20. pp. 67-75. ISSN 1526-0542

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It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a priori criteria for inclusion and exclusion of studies. The initial search yielded 29,351 citations of which 208 articles were reviewed in full and 25 were included in the review. This included 6 birth cohorts and 19 longitudinal population studies. The 25 studies reported the effect of 74 childhood factors (on their own or in combinations with other factors) on subsequent lung function reported as percent predicted forced expiration in one second (FEV1). The childhood factors that were associated with a significant reduction in future FEV1 could be grouped as: early infection, bronchial hyper-reactivity (BHR) / airway lability, a diagnosis of asthma, wheeze, family history of atopy or asthma, respiratory symptoms and prematurity / low birth weight. A complete mathematical model will only be possible if the raw data from all previous studies is made available. This highlights the need for increased cooperation between researchers and the need for international consensus about the outcome measures for future longitudinal studies.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://dx.doi.org/10.1016/j.prrv.2016.03.003 Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Paediatrics, Lung function, Asthma, COPD, Infection, Bronchiolitis, Prematurity, Bronchial hyper-reactivity
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > School of Allied Health Professions
Depositing User: Symplectic
Date Deposited: 15 Mar 2016 09:37
Last Modified: 10 Jan 2020 14:15
URI: https://eprints.keele.ac.uk/id/eprint/1565

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