Hulme, W, Sperrin, M, Rushton, H, Ludman, P, De Belder, M, Curzen, N, Kinnaird, T, Kwok, CS, Buchan, I, Nolan, J and Mamas, M (2016) Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society. Circulation: Cardiovascular Interventions, 9 (5). ISSN 1941-7632

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Radial volume manuscript 16Jan2016 WH MM (1).pdf - Accepted Version
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Background: Transradial access (TRA) is associated with reduced access site related bleeding complications and mortality post percutaneous coronary intervention (PCI). The objective of this study is to examine the relationship between access site practice and clinical outcomes and how this may be influenced by operator and center experience/expertise. Methods and Results: The influence of operator and center experience/expertise was studied on 30-day mortality, in-hospital MACE (a composite of in-hospital mortality and in-hospital myocardial infarction and target vessel revascularization) and in-hospital major bleeding based on access site adopted (radial vs femoral). Operator/center experience/expertise were defined by both total volume and TRA proportion. A total of 164,395 procedures between 2012 and 2013 in the NHS in England and Wales were analyzed. After case-mix adjustment, TRA was associated with an average odds reduction of 39% for 30-day mortality compared with transfemoral access (TFA) (OR = 0.61, 95% CI 0.55-0.68, p<0.001). The magnitude of this risk reduction was modified by increases in total procedural volume and radial proportion at the operator level (OR reduction of 11% per 100 extra procedures, 95% CI 3-19%; OR reduction of 6% per 10%-point increase in radial proportion, 95% CI 1-11%) with no significant impact of operator radial volume, center total volume, center radial volume and center radial proportion. Conclusions: The lower mortality associated with TRA adoption relates to both the total procedural volume and the proportion of procedures undertaken radially by operator, with operators undertaking the greatest proportion of their procedures radially having the largest relative reduction in mortality risk.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via American Heart Association at Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: hemorrhage, mortality, myocardial infarction, percutaneous coronary intervention, risk reduction
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 30 Mar 2016 08:14
Last Modified: 25 Jun 2018 12:51

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