Bagur, R, Kwok, CS, Nombela-Franco, L, Ludman, PF, DeBelder, MA, Sponga, S, Gunning, M, Nolan, J, Kiaii, B, Diamantouros, P, Teefy, P, Chu, M and Mamas, M (2016) Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis. Journal of the American Heart Association, 67 (3). p. 411. ISSN 2047-9980

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TAVI with or without BAV SR and MA - 2016-02-15 - JAHA-2015-003191-R1.pdf - Accepted Version
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Objectives: Pre-implantation balloon-aortic valvuloplasty (BAV) is considered routine procedure during transcatheter aortic valve implantation (TAVI) to facilitate prosthesis implantation and expansion; however, it has been speculated that fewer embolic events and/or hemodynamic instability may occur if TAVI is performed without pre-implantation BAV. Hence, the aim of the study was to systematically review the clinical outcomes associated with TAVI undertaken without pre-implantation BAV. Methods and Results: We conducted a search of MEDLINE and EMBASE to identify studies that evaluated patients who underwent TAVI with/without pre-implantation BAV for predilation. Pooled analysis and random effects meta-analyses were used to estimate the rate and risk of adverse outcomes. Sixteen studies involving 1395 patients (674/721 with/without preimplantation BAV) fulfilled the inclusion criteria. Crude device success was achieved in 94% (1311/1395) and 30-day all-cause mortality occurred in 6% (72/1282) of patients. Meta-analyses evaluating outcomes between pre-implantation BAV versus without BAV strategies showed no statistically significant differences in terms of mortality (risk ratio [RR]: 0.61, 95% confidence interval [CI]: 0.32-1.14, P=0.12), safety composite endpoint (RR: 0.85, 95%CI: 0.62-1.18, P=0.34), moderate-to-severe paravalvular leaks (RR: 0.68, 95%CI: 0.23-1.99, P=0.48), need for postdilation (RR: 0.86, 95%CI: 0.66-1.13, P=0.58), stroke and/or transient ischemic attack (RR: 0.72, 95%CI: 0.30-1.71, P=0.45), and permanent pacemaker implantation (RR: 0.80, 95%CI: 0.49-1.30, P=0.37). Conclusion: Our analysis suggests that TAVI procedures with or without pre-implantation BAV were associated with similar outcomes in a number of clinically relevant endpoints. Further Disclaimer: The manuscript and its contents are confidential, intended for journal review purposes only, and not to be further disclosed. JAHA/2015/003191-R1 3 studies including a significant number of patients are needed to ascertain the impact of TAVI without pre-implantation BAV as a standard practice.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via American Heart Association at - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: aortic stenosis, TAVI, TAVR, balloon-expandable, self-expandable, balloon valvuloplasty
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
R Medicine > RD Surgery > RD32 Operative surgery. Technique of surgical operations
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 21 Apr 2016 15:35
Last Modified: 30 Mar 2021 14:30

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