Danbolt, NC, Furness, DN and Zhou, Y (2016) Neuronal vs glial glutamate uptake: Resolving the conundrum. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, 98. pp. 29-45. ISSN 1872-9754

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Neither normal brain function nor the pathological processes involved in neurological diseases can be adequately understood without knowledge of the release, uptake and metabolism of glutamate. The reason for this is that glutamate (a) is the most abundant amino acid in the brain, (b) is at the cross-roads between several metabolic pathways, and (c) serves as the major excitatory neurotransmitter. In fact most brain cells express glutamate receptors and are thereby influenced by extracellular glutamate. In agreement, brain cells have powerful uptake systems that constantly remove glutamate from the extracellular fluid and thereby limit receptor activation. It has been clear since the 1970s that both astrocytes and neurons express glutamate transporters. However the relative contribution of neuronal and glial transporters to the total glutamate uptake activity, however, as well as their functional importance, has been hotly debated ever since. The present short review provides (a) an overview of what we know about neuronal glutamate uptake as well as an historical description of how we got there, and (b) a hypothesis reconciling apparently contradicting observations thereby possibly resolving the paradox.

Item Type: Article
Uncontrolled Keywords: glutamate uptake; EAAT2; glutamate transporter; conditional knockout; synaptosomes; Axon-terminals
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Natural Sciences > School of Life Sciences
Depositing User: Symplectic
Date Deposited: 26 May 2016 08:10
Last Modified: 12 Apr 2019 12:40
URI: https://eprints.keele.ac.uk/id/eprint/1781

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