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Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus Thumbnail


Abstract

The intervertebral disc in the spine and the meniscus in the knee are two fibrocartilaginous tissues which commonly are injured or become degenerate, causing significant clinical problems. The principals of tissue engineering, which are applicable elsewhere in the body, hold true for the disc and meniscus. Whilst there are some similarities with articular cartilage in terms of the molecules present, these fibrocartilages have their own peculiarities, some of which can be quite challenging. Following a description of the structure and anatomy of the disc and meniscus and the current clinical treatments, the different strategies for biological repair are described focusing particularly on cell therapy. The types of cells and scaffolds being investigated and how these can be modified are discussed.

Acceptance Date Jun 22, 2016
Publication Date Aug 27, 2016
Publicly Available Date Mar 29, 2024
Journal Reference Module in Biomedical Sciences
Pages 321-329
DOI https://doi.org/10.1016/B978-0-12-801238-3.99809-X
Keywords back pain; cell therapy; clinical applications; collagens; meniscal injury; proteoglycans; regenerative medicine; scaffolds
Publisher URL https://doi.org/10.1016/B978-0-12-801238-3.99809-X

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