Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.

Mennan, Claire; Wright, Karina; Bhattacharjee, Atanu; Balain, Birender; Richardson, James; Roberts, Sally

doi:10.1155/2013/916136

Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.

Mennan, Claire; Wright, Karina; Bhattacharjee, Atanu; Balain, Birender; Richardson, James; Roberts, Sally

Authors

Claire Mennan c.mennan@keele.ac.uk

Karina Wright k.t.wright@keele.ac.uk

Atanu Bhattacharjee

Birender Balain

James Richardson

Sally Roberts

Abstract

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, including artery, vein, cord lining, and Wharton's jelly, are described in the literature. However, no one study has yet isolated and characterised MSCs from all regions of the same cord to determine the most suitable cells for cell based therapeutics.

Journal Article Type	Article
Acceptance Date	Jun 13, 2013
Publication Date	Jun 13, 2013
Journal	BioMed Research International
Print ISSN	2314-6133
Publisher	Hindawi
Peer Reviewed	Peer Reviewed
Volume	2013
Article Number	916136
DOI	https://doi.org/10.1155/2013/916136
Keywords	cell differentiation, cell proliferation, cell separation, chondrogenesis, dissection, flow cytometry, humans, mesenchymal stromal cells, umbilical cord
Publisher URL	http://dx.doi.org/10.1155/2013/916136