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Wright, KT, El Masri, W, Osman, A, Chowdhury, J and Johnson, WE (2011) Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Application. Stem Cells, 29 (2). pp. 169-178. ISSN 1549-4918

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Abstract

Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; haematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into CNS cells, but focus on the neurotrophic, tissue sparing and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues relating to the translation of HSC and MSC therapies for SCI patients and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date.

Item Type: Article
Uncontrolled Keywords: Adult human bone marrow, Spinal cord injury, Cell transplantation, Clinical translations and clinical trials
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 22 Nov 2016 14:23
Last Modified: 15 Mar 2021 16:10
URI: https://eprints.keele.ac.uk/id/eprint/2465

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