Marshall, MJ, Evans, SF, Sharp, CA, Powell, DE, McCarthy, HS and Davie, MWJ (2009) Increased circulating Dickkopf-1 in Paget's disease of bone. Clinical Biochemistry, 42 (10/11). pp. 965-969. ISSN 1873-2933

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Dickkopf-1 (Dkk-1) is a secreted inhibitor of Wnt signaling which in adults regulates bone turnover. Dkk-1 over-production is implicated in osteolytic disease where it inhibits bone formation and stimulates bone breakdown. Recently it was reported that osteoblastic cells from Paget's disease of bone (PDB) over-expressed Dkk-1.

To see if increased Dkk-1 was detected in serum from patients with PDB.

Dkk-1 and total serum alkaline phosphatase activity (tsAP) were significantly elevated in sera from PDB patients. Patients with polyostotic PDB had significantly higher levels of tsAP but not Dkk-1, than monostotic patients. TsAP but not Dkk-1, was significantly lower in sera from bisphosphonate treated versus untreated PDB patients. Dkk-1 and tsAP were not significantly correlated.

Dkk-1 may be a useful biomarker of PDB and we speculate that Dkk-1 may play a central role in the etiology of PDB.

Item Type: Article
Uncontrolled Keywords: Dickkopf-1, Serum, Paget's disease of bone, Alkaline phosphatase, Wnt, Inhibitor
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 15 Dec 2016 15:49
Last Modified: 08 Jul 2019 13:48

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