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Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Rosaria Capobianchi, Maria; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z.; Lima, Marcelo A.; Skidmore, Mark; Broccoli, Vania; Yates, Edwin A.; Vicenzi, Elisa

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Authors

Silvia Ghezzi

Lynsay Cooper

Alicia Rubio

Isabel Pagani

Maria Rosaria Capobianchi

Giuseppe Ippolito

Julien Pelletier

Maria Cecilia Z. Meneghetti

Vania Broccoli

Edwin A. Yates

Elisa Vicenzi



Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Journal Article Type Article
Acceptance Date Dec 29, 2016
Publication Date Jan 5, 2017
Publicly Available Date Mar 29, 2024
Journal Antiviral Research
Print ISSN 0166-3542
Electronic ISSN 1872-9096
Publisher Elsevier
Volume 140
Pages 13-17
DOI https://doi.org/10.1016/j.antiviral.2016.12.023
Keywords Cell death, Heparin, Neural progenitor cells, Zika virus (ZIKV), Cell Death, Cytopathogenic Effect, Viral, Drug Repositioning, Heparin, Humans, Neural Stem Cells, Zika Virus
Publisher URL https://www.ncbi.nlm.nih.gov/pubmed/28063994

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