Silvia Ghezzi
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Rosaria Capobianchi, Maria; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z.; Lima, Marcelo A.; Skidmore, Mark; Broccoli, Vania; Yates, Edwin A.; Vicenzi, Elisa
Authors
Lynsay Cooper
Alicia Rubio
Isabel Pagani
Maria Rosaria Capobianchi
Giuseppe Ippolito
Julien Pelletier
Maria Cecilia Z. Meneghetti
Marcelo Andrade De Lima m.andrade.de.lima@keele.ac.uk
Mark Skidmore m.a.skidmore@keele.ac.uk
Vania Broccoli
Edwin A. Yates
Elisa Vicenzi
Abstract
The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 29, 2016 |
Publication Date | Jan 5, 2017 |
Publicly Available Date | Mar 29, 2024 |
Journal | Antiviral Research |
Print ISSN | 0166-3542 |
Electronic ISSN | 1872-9096 |
Publisher | Elsevier |
Volume | 140 |
Pages | 13-17 |
DOI | https://doi.org/10.1016/j.antiviral.2016.12.023 |
Keywords | Cell death, Heparin, Neural progenitor cells, Zika virus (ZIKV), Cell Death, Cytopathogenic Effect, Viral, Drug Repositioning, Heparin, Humans, Neural Stem Cells, Zika Virus |
Publisher URL | https://www.ncbi.nlm.nih.gov/pubmed/28063994 |
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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