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Ghezzi, S, Cooper, L, Rubio, A, Pagani, I, Capobianchi, M, Ippolito, G, Pelletier, J, Meneghetti, MC, Lima, M, Skidmore, MA, Broccoli, V, Yates, E and Vicenzi, E (2017) Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140. pp. 13-17. ISSN 0166-3542

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M Skidmore - Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.pdf - Accepted Version
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Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.antiviral.2016.12.023 Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Zika Virus; Neural progenitor cells; Heparin; Cell death
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Natural Sciences > School of Life Sciences
Depositing User: Symplectic
Date Deposited: 05 Jan 2017 14:56
Last Modified: 19 Jun 2018 11:45
URI: https://eprints.keele.ac.uk/id/eprint/2722

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