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A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death

Abstract

Pro-inflammatory cytokines are known inducers of beta cell death in the pathogenesis of Type 1 diabetes and mediate their effects through the perturbation of multiple regulatory gene networks. GAS5, a long non-coding RNA whose expression negatively correlates with cell survival in cancer cell lines, was previously identified by DNA microarray analysis as overexpressed in INS1 cells in response to inflammatory cytokines. This study aimed to confirm GAS5 expression by RT-PCR and its functional effects on beta cell survival in BRIN-BD11 cells.

Acceptance Date Mar 11, 2015
Publication Date Mar 11, 2015
Publicly Available Date Mar 29, 2024
Journal Diabetic Medicine
Print ISSN 0742-3071
Publisher Wiley
Pages 39 - 39
DOI https://doi.org/10.1111/dme.12668
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/dme.12668/full

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