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Cunningham, R, Barringer, R, Hussain, R and Watson, D (2015) A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death. Diabetic Medicine, 32. 39 - 39. ISSN 1464-5491

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A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death.docx - Accepted Version
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Abstract

Pro-inflammatory cytokines are known inducers of beta cell death in the pathogenesis of Type 1 diabetes and mediate their effects through the perturbation of multiple regulatory gene networks. GAS5, a long non-coding RNA whose expression negatively correlates with cell survival in cancer cell lines, was previously identified by DNA microarray analysis as overexpressed in INS1 cells in response to inflammatory cytokines. This study aimed to confirm GAS5 expression by RT-PCR and its functional effects on beta cell survival in BRIN-BD11 cells.

Item Type: Article
Additional Information: "This is the peer reviewed version of the following article: "A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death", which has been published in final form at 10.1111/dme.12668. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology
R Medicine > R Medicine (General)
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 02 Feb 2017 12:29
Last Modified: 18 Mar 2021 16:07
URI: https://eprints.keele.ac.uk/id/eprint/2856

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