Butler, R, Mamas, M and Sandhu, K (2017) Endothelial progenitor cells: exploring the pleiotropic effects of statins. World Journal of Cardiology, 9 (1). pp. 1-13. ISSN 1949-8462

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Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct and or death after a myocardial infarction, prior to any significant change in lipid profile. Therefore, pleiotropic mechanisms, other than lowering lipid profile alone, must account for this effect. One such proposed pleiotropic mechanism is the ability of statins to augment both number and function of endothelial progenitor cells. The ability to augment repair and maintenance of a functioning endothelium may have profound beneficial effect on vascular repair and potentially a positive impact on clinical outcomes in patients with cardiovascular disease. The following literature review will discuss issues surrounding endothelial progenitor cell (EPC) identification, role in vascular repair, factors affecting EPC numbers, the role of statins in current medical practice and their effects on EPC number.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Baishideng Publishing Group Co. Limited at http://dx.doi.org/10.4330/wjc.v9.i1.1 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: statins, endothelial progenitor cells, pleiotropic effects, ischaemic heart disease, pleiotropic mechanisms
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 13 Feb 2017 10:12
Last Modified: 02 Apr 2019 14:56
URI: https://eprints.keele.ac.uk/id/eprint/2889

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