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Biological challenges for regeneration of the degenerated disc using cellular therapies

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Abstract

In this review, we discuss some of the challenges in successful cellular repair of the disc. We fi rst review the function, organization, and composition of a normal disc, outline the changes that occur in degeneration, and consider how these might infl uence function. We then summarize cell therapy approaches to repairing the disc in relation to the choice of cells and cell support. We outline the challenges facing the implanted cells in the degenerate disc, and ask whether these therapies can be evaluated in animal models. Finally, we outline the important, but often neglected, problem of patient selection.

Acceptance Date Jan 17, 2017
Publication Date Dec 16, 2016
Publicly Available Date Mar 29, 2024
Journal Acta Orthopaedica
Print ISSN 1745-3674
Publisher Informa Healthcare
Pages 39 -46
DOI https://doi.org/10.1080/17453674.2017.1297916
Publisher URL http://dx.doi.org/10.1080/17453674.2017.1297916

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