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Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain

Jozwiak, A; Liu, Y; Yang, Y; Gates, M

Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain Thumbnail


Authors

A Jozwiak

Y Liu



Abstract

Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. Here, novel technology has been developed that allows for the implantation of neural constructs or intact pieces of neural tissue into the CNS with low trauma. By "laying out" (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. Such technology may be useful for treating various CNS disorders which require the reestablishment of point-to-point contacts (e.g., Parkinson's disease) across the adult CNS, an environment which is not normally permissive to axonal growth.

Acceptance Date Nov 20, 2013
Publication Date Jan 23, 2014
Publicly Available Date Mar 29, 2024
Journal BioMed Research International
Print ISSN 2314-6133
Publisher Hindawi
Pages 651236 -?
DOI https://doi.org/10.1155/2014/651236
Keywords surgery, brain surgery, central nervous system, stereotaxic techniques, animals, parkinson disease, tissue engineering

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