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Hariprakash, S, Alexander, J, Carroll, W, Ramesh, P, Randell, T, Turnbull, F and Lenney, W (2003) Randomized controlled trial of nebulized adrenaline in acute bronchiolitis. Pediatric Allergy and Immunology, 14 (2). 134 - 139. ISSN 0905-6157
Full text not available from this repository.Abstract
Use of both l-epinephrine and racemic epinephrine (adrenaline) has improved clinical symptoms and composite respiratory scores in acute bronchiolitis. The objective of this randomized double-blind placebo-controlled study was to assess whether there was sufficient improvement in clinical state to reduce hospital admissions. Seventy-five infants aged 1 month to 1 year with a clinical diagnosis of acute bronchiolitis were treated with either 2 ml of 1:1000 nebulized adrenaline or 2 ml of nebulized normal saline administered after baseline assessment and 30 min later. Clinical respiratory parameters were recorded at 15-min intervals for a period of 2 h following the baseline assessment. Admission to hospital was the primary end-point and changes in respiratory parameters were secondary end-points. Fifty percent (19/38) of infants treated with adrenaline were discharged home compared with 38 percent (14/37) of those treated with saline. This 12 percent reduction in rate of admission is not statistically significant (95% CI of difference: -10% to 35%). There was no difference between treated and placebo groups in respiratory rate, oxygen saturation, heart rate or a composite respiratory distress score at 30, 60 or 120 min post-treatment. In this study, nebulized epinephrine did not confer a significant advantage over nebulized saline in the emergency room treatment of acute bronchiolitis.
Item Type: | Article |
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Additional Information: | © 1999 - 2017 John Wiley & Sons, Inc. All Rights Reserved |
Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC705 Diseases of the respiratory system R Medicine > RJ Pediatrics |
Divisions: | Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 05 Jun 2017 15:01 |
Last Modified: | 05 Jun 2017 15:01 |
URI: | https://eprints.keele.ac.uk/id/eprint/3388 |