Kouzouna, A, Gilchrist, FJ, Ball, V, Kyriacou, T, Henderson, J, Pandyan, AD and Lenney, W (2016) A systematic review of early life factors which adversely affect subsequent lung function. Paediatric Respiratory Reviews, 20. 67 -75. ISSN 1526-0542

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It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a priori criteria for inclusion and exclusion of studies. The initial search yielded 29,351 citations of which 208 articles were reviewed in full and 25 were included in the review. This included 6 birth cohorts and 19 longitudinal population studies. The 25 studies reported the effect of 74 childhood factors (on their own or in combinations with other factors) on subsequent lung function reported as percent predicted forced expiration in one second (FEV1). The childhood factors that were associated with a significant reduction in future FEV1 could be grouped as: early infection, bronchial hyper-reactivity (BHR) / airway lability, a diagnosis of asthma, wheeze, family history of atopy or asthma, respiratory symptoms and prematurity / low birth weight. A complete mathematical model will only be possible if the raw data from all previous studies is made available. This highlights the need for increased cooperation between researchers and the need for international consensus about the outcome measures for future longitudinal studies.

Item Type: Article
Uncontrolled Keywords: asthma, bronchial hyper-reactivity, bronchiolitis, COPD, child, disease progression, forced expiratory volume, humans, infection, lung, lung function, paediatrics, prematurity, respiratory tract diseases, risk factors
Subjects: R Medicine > RC Internal medicine > RC705 Diseases of the respiratory system
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine and Health Sciences > Institute for Applied Clinical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 11 May 2017 12:54
Last Modified: 22 Nov 2018 12:17
URI: https://eprints.keele.ac.uk/id/eprint/3408

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