Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system.

O'Brien, M; Konings, L; Martin, M; Heap, J

doi:10.1016/j.tetlet.2017.05.008

Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system.

O'Brien, M; Konings, L; Martin, M; Heap, J

Authors

Matthew O'Brien m.obrien@keele.ac.uk

L Konings

M Martin

J Heap

Abstract

An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-liquid extraction step was used to provide effective inline purification. A Raspberry Pi single-board computer was employed to interface with the motors used in the autosampler and actuated fluidic valves.

Acceptance Date	May 3, 2017
Publication Date	May 5, 2017
Journal	Tetrahedron Letters
Print ISSN	0040-4039
Publisher	Elsevier
Pages	2409-2413
DOI	https://doi.org/10.1016/j.tetlet.2017.05.008
Keywords	open-source, automation, flow chemistry, desilylation, liquid-liquid extraction
Publisher URL	https://doi.org/10.1016/j.tetlet.2017.05.008

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