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O'Brien, M, Konings, L, Martin, M and Heap, J (2017) Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system. Tetrahedron Letters, 58 (25). pp. 2409-2413. ISSN 0040-4039

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Abstract

An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-liquid extraction step was used to provide effective inline purification. A Raspberry Pi single-board computer was employed to interface with the motors used in the autosampler and actuated fluidic valves.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.tetlet.2017.05.008 Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: open-source, automation, flow chemistry, desilylation, liquid-liquid extraction
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Depositing User: Symplectic
Date Deposited: 30 May 2017 10:04
Last Modified: 11 Jan 2019 14:02
URI: https://eprints.keele.ac.uk/id/eprint/3503

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