Matthew O'Brien m.obrien@keele.ac.uk
Continuous flow iodination using an automated computer-vision controlled liquid-liquid extraction system
O'Brien, M; Cooper, DA; Dolan, Jonathan
Abstract
Abstract A dynamic computer-vision control system incorporating open-source software technologies (Python, OpenCV) was used to automate a gravity based in-line liquid-liquid extraction during the iodination of enaminones in continuous flow. The system was able to cope with significant colouration of the organic reaction stream and with significant volume/flow changes in the aqueous and organic phase streams due to extraction of the water soluble acetonitrile co-solvent.
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Jan 10, 2017 |
| Publication Date | Mar 1, 2017 |
| Journal | Tetrahedron Letters |
| Print ISSN | 0040-4039 |
| Publisher | Elsevier |
| Pages | 829 - 834 |
| DOI | https://doi.org/10.1016/j.tetlet.2017.01.029 |
| Keywords | open-source, automation, computer-vision, continuous-flow, iodination |
| Publisher URL | http://www.sciencedirect.com/science/article/pii/S0040403917300515 |
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