Monahan, M, Ensor, J, Moore, D, Fitzmaurice, D and Jowett, S (2017) Economic evaluation of strategies for restarting anticoagulation therapy after a first event of unprovoked venous thromboembolism. Journal of Thrombosis and Haemostasis, 15 (8). pp. 1591-1600. ISSN 1538-7836

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BACKGROUND: Following at least three months of anticoagulation therapy after a first unprovoked Venous Thromboembolism (VTE), there is uncertainty about the duration of therapy. Further anticoagulation therapy reduces the risk of having a potentially fatal recurrent VTE but at the expense of a higher risk of bleeding which can also be fatal. OBJECTIVE: An economic evaluation sought to estimate the long-term cost-effectiveness of using a decision rule for restarting anticoagulation therapy versus no extension of therapy in patients based on their risk of a further unprovoked VTE. METHODS: A Markov patient-level simulation model was developed which adopted a lifetime time horizon with monthly time cycles and was from a UK National Health Service (NHS) /Personal Social Services (PSS) perspective. RESULTS: Base case model results suggest that treating patients with a predicted one year VTE risk of 17.5% or higher may be cost-effective if decision makers are willing to pay up to £20,000 per Quality Adjusted Life Year (QALY) gained. However probabilistic sensitivity analysis show the model was highly sensitive to overall parameter uncertainty and warrants caution in selecting the optimal decision rule on cost-effectiveness grounds. Univariate sensitivity analyses indicate variables such as anticoagulation therapy disutility and mortality risks were very influential for driving model results. CONCLUSION: This represents the first economic model to consider the use of a decision rule for restarting therapy for unprovoked VTE patients. Better data are required to predict long-term bleeding risks on therapy in this patient group. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Wiley at Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: cost-benefit analysis; deep vein thrombosis; medical economics; pulmonary embolism; venous thromboembolism

R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 30 May 2017 15:26
Last Modified: 08 Apr 2021 10:30

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