King, A, Troakes, C, Aizpurua, M, Mirza, A, Hodges, A, Al-Sarraj, S and Exley, C (2017) Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK. Neuropathology and Applied Neurobiology, 43 (6). pp. 537-541. ISSN 1365-2990

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The possible role of aluminium in the pathogenesis of Alzheimer's disease (AD) has been hotly debated over the past few decades. Although the so‐called ‘aluminium hypothesis’ was popular in the 1970s and 1980s, it has gradually fallen out of favour in the past few years possibly following a number of inconclusive and contradictory human environmental/clinical studies. Nevertheless, there have from time to time been reminders in the media of environmental accidents; these have prevented the topic from disappearing completely from public memory. One such accident occurred on July 6th 1988 in Camelford, Cornwall when 20 tonnes of aluminium sulphate was mistakenly discharged into the mains water supply. Twenty thousand people were exposed to concentrations of aluminium which were 500–3000 times the acceptable limit under European Union legislation. Over the subsequent years there have been UK government inquiries into the supposed environmental impact and occasional clinical follow‐up studies documenting declining cerebral function in those exposed to the contaminated water but very little neuropathological data has been published. To our knowledge, the case described here is only the second neuropathological description.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Wiley at - please refer to any applicable terms of use of the publisher.
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 14 Sep 2017 09:25
Last Modified: 19 Mar 2019 10:05

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