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Morgan, E (2015) Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40. MedChemComm, 6 (6). pp. 1024-1029. ISSN 2040-2511
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David Morgan - Discovery of a series of 2-(pyridinyl)pyrimidines as potent antagonists of GPR40.pdf
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Official URL: https://doi.org/10.1039/c5md00037h
Abstract
A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable in vivo probe compound, which was confirmed to exhibit pharmacology consistent with GPR40 antagonism.
Item Type: | Article |
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Subjects: | Q Science > QD Chemistry |
Divisions: | Faculty of Natural Sciences > School of Physical and Geographical Sciences |
Depositing User: | Symplectic |
Date Deposited: | 22 Apr 2015 11:07 |
Last Modified: | 02 May 2019 11:26 |
URI: | https://eprints.keele.ac.uk/id/eprint/417 |
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