Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis

Abstract

AbstractBackground Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete unusually high amounts of aluminium in their urine. Silicon-rich mineral waters facilitate the removal of aluminium from the body in urine and herein we have tested their efficacy in affecting urinary excretion of aluminium in individuals diagnosed with secondary progressive multiple sclerosis (SPMS). Methods Urinary excretion of aluminium and silicon, measured using transversely-heated graphite furnace atomic absorption spectrometry, was determined in 15 individuals diagnosed with SPMS over 24 weeks, a 12 week baseline period (control) followed by a 12 week treatment period, during which individuals consumed up to 1.5 L of a silicon-rich mineral water every day. Findings Individuals with SPMS excreted high amounts of aluminium during the baseline period (135.2 nmol/mmol Crt (70.3–222.2, n = 180) and females excreted significantly more aluminium than males. Regular drinking of a silicon-rich mineral water increased the urinary excretion of aluminium significantly (349.0 nmol/mmol Crt (231.7–524.7, n = 180; three-way ANOVA, F1,13 = 59.17, p-value = 0.000003) relative to the baseline period. The majority of individuals, 14 out of 15, excreted more aluminium (µmol/24 h) following drinking of a silicon-rich mineral water (independent-test, p < 0.05). Silicon-rich mineral waters may be an effective and non-invasive therapy for the removal of aluminium from the body of individuals with SPMS.