Keele Research Repository

When it comes to cell proliferation, this is a process strictly controlled by extracellular signals, such as nutrients, growth factors, temperature, and more. Together, these establish the cell cycle control mechanism, which is the core of cell proliferation.
Throughout the current review, a collection of the most pertinent background sources was built, in order to investigate the cytoprotective effect of cooling in opposition to toxicity brought on by chemotherapy, and subsequently another experimental approach was developed to comprehend the impacts of cooling on cell cycle arrest in cell culture. As a result, it is considered that this could show an approach for reaching selective toxicity of chemotherapeutic agents for cells, which in turn can provide a deeper comprehension of the molecular and cellular processes occurring within. With detailed information collected regarding the way that cell cycle events are controlled, it is considered that innovative ways of using this to protect for chemotherapy-induced alopecia will be established.