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Ragazzon, P, McGown, A, Ragazzon-Smith, A, Hadfield, J and Potgetier, H (2019) Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents. Letters in Organic Chemistry, 16 (1). pp. 66-75. ISSN 1570-1786

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Abstract

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Ingenta Connect at http://doi.org/10.2174/1570178615666180621094529 - Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Flavonoid; bis-flavonoid; green-chemistry; click-chemistry; microwave-assisted chemistry; anticancer
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Medicine and Health Sciences > School of Pharmacy
Depositing User: Symplectic
Date Deposited: 25 Jun 2018 15:50
Last Modified: 17 Aug 2020 15:10
URI: https://eprints.keele.ac.uk/id/eprint/5025

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