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Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells

Watkinson

Authors

Watkinson



Abstract

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.

Acceptance Date Jul 27, 2018
Publication Date Sep 7, 2018
Publicly Available Date Mar 28, 2024
Journal Chemical Communications
Print ISSN 1359-7345
Publisher Royal Society of Chemistry
Pages 9619-9266
DOI https://doi.org/10.1039/c8cc05425h
Publisher URL http://doi.org/10.1039/c8cc05425h