Bursill, D, Taylor, WJ, Terkeltaub, R, Kuwabara, M, Merriman, TR, Grainger, R, Pineda, C, Louthrenoo, W, Edwards, NL, Andrés, M, Vargas-Santos, AB, Roddy, E, Pascart, T, Lin, C-T, Perez-Ruiz, F, Tedeschi, SK, Kim, SC, Harrold, LR, McCarthy, G, Kumar, N, Chapman, PT, Tausche, A-K, Vazquez-Mellado, J, Gutierrez, M, Pinheiro, GDRC, Richette, P, Pascual, E, Fisher, MC, Burgos-Vargas, R, Robinson, PC, Singh, JA, Jansen, TL, Saag, KG, Slot, O, Uhlig, T, Solomon, DH, Keenan, RT, Scire, CA, Biernat-Kaluza, E, Dehlin, M, Nuki, G, Schlesinger, N, Janssen, M, Stamp, LK, Sivera, F, Reginato, AM, Jacobsson, L, Lioté, F, Ea, H-K, Rosenthal, A, Bardin, T, Choi, HK, Hershfield, MS, Czegley, C, Choi, SJ and Dalbeth, N (2019) Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions for disease elements in gout. Arthritis Care and Research, 71 (3). pp. 427-434. ISSN 2151-4658

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The language currently used to describe gout lacks standardisation. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout.

METHODS: Experts in gout (n=130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labelling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting.

There were 51 respondents to the Delphi exercise and 30 attendees at the face-to-face meeting. Consensus agreement (≥80%) was achieved for the labels of eight disease elements through the Delphi exercise; the remaining three labels reached consensus agreement through the face-to-face consensus meeting. The agreed labels were: monosodium urate crystals, urate, hyperuric(a)emia, tophus, subcutaneous tophus, gout flare, intercritical gout, chronic gouty arthritis, imaging evidence of monosodium urate crystal deposition, gouty bone erosion and podagra. The face-to-face meeting achieved consensus agreement for the definitions of all 11 elements and a recommendation that the label 'chronic gout' should not be used.

Consensus agreement was achieved for the labels and definitions of 11 elements representing the fundamental components of gout aetiology, pathophysiology and clinical presentation. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) recommends the use of these labels when describing the basic disease elements of gout.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Wiley at https://doi.org/10.1002/acr.23607 - Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: gout, nomenclature, terminology, urate
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 18 Sep 2018 14:30
Last Modified: 29 Apr 2021 14:52
URI: https://eprints.keele.ac.uk/id/eprint/5329

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