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Miller, GJ, O'Brien, M, Jones, RH, Dimitriou, E and Pritchard, R (2018) Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold. Tetrahedron, 74 (47). pp. 6795-6803. ISSN 0040-4020

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Abstract

Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.tet.2018.09.025. Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Gas-liquid flow, Hydrogenation, Pyrrolobenzodiazepine, Reduction, Cyclisation
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Depositing User: Symplectic
Date Deposited: 24 Sep 2018 08:59
Last Modified: 11 Sep 2019 01:30
URI: https://eprints.keele.ac.uk/id/eprint/5350

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