Buture, A, Ahmed, F, Dikomitis, LA and Boland, JW (2019) Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache. Neurological Sciences, 40 (1). pp. 25-39. ISSN 1590-1874

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Patients with cluster headache (CH), the most common trigeminal autonomic cephalalgia, often face delayed diagnosis, misdiagnosis and mismanagement.

Objectives. To identify, appraise and synthesise clinical studies on the delays in diagnosis and misdiagnosis of CH in order to determine its causes and help the management of this condition.

The systematic review was prepared, conducted and reported in accordance with the Preferred reporting items for systematic review and meta-analysis. It was registered with International Prospective Register of Systematic Reviews. A systematic search of different
electronic databases (Medline, EMBASE, PsycINFO, PubMed, CINAHL, BNI, HMIC, AMED, HBE and Cochrane Library) was carried out in May 2017. Reference lists of relevant articles were hand searched.

The search identified 201 unique studies. Fifteen studies met the inclusion criteria of which 13 case series studies and two survey studies. Nine studies assessed the delays in diagnosis and misdiagnosis of CH, five studies the delays in diagnosis and one study the
misdiagnosis of CH. The studies included 4661 patients. Delays in diagnosis, misdiagnosis and mismanagement have been reported in many European countries, Japan and in USA with well-developed health services. The patients with CH often visited many different clinicians,
surgeons and dentists and received multiple diagnosis prior to being correctly diagnosed.

This systematic review shows that the delays in the diagnosis of CH is a widespread problem, the time to diagnosis still vary from country to country and both patients and physicians are responsible for the delays in diagnosis.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) will be available online via Springer at https://link.springer.com/journal/10072 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: diagnostic error, diagnostic mistake, therapeutic error, mismanagement, unrecognised diagnosis
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 02 Oct 2018 08:28
Last Modified: 29 Sep 2019 01:30
URI: https://eprints.keele.ac.uk/id/eprint/5396

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