Greenwood, CE, Clement, JG, Dicken, AJ, Evans, JPO, Lyburn, ID, Martin, RM, Rogers, KD, Stone, N and Zioupos, P (2018) Age Related Changes in Femoral Head Trabecular Architecture. Aging and Disease, 9 (6). pp. 1-12. ISSN 2152-5250

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Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density using dual energy X-ray absorption. However, many studies have shown that bone strength, and consequently the probability of fracture, is a combination of both bone mass and bone ‘quality’ (architecture and material chemistry). Although the microarchitecture of both non-fracture and osteoporotic bone has been previously investigated, many of the osteoporotic studies are constrained by factors such as limited sample number, use of ovariectomised animal models, and lack of male and female discrimination. This study reports significant differences in bone quality with respect to the microarchitecture between fractured and non–fractured human femur specimens. Micro-computed tomography was utilised to investigate the microarchitecture of femoral head trabecular bone from a relatively large cohort of non-fracture and fracture human donors. Various microarchitectural parameters have been determined for both groups, providing an understanding of the differences between fracture and non –fracture material. The microarchitecture of non-fracture and fracture bone tissue is shown to be significantly different for many parameters. Differences between sexes also exist, suggesting differences in remodelling between males and females in the fracture group. The results from this study will, in the future, be applied to develop a fracture model which encompasses bone density, architecture and material chemical properties for both female and male tissues.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Buck Institute for Age Research at - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: micro computed tomography (μ-CT), osteoporosis, aging, microarchitecture, trabecular bone, femoral head
Subjects: R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Depositing User: Symplectic
Date Deposited: 08 Oct 2018 13:40
Last Modified: 29 Mar 2021 10:48

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