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Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases

Ahmadipour, Sanaz; Beswick, Laura; Miller, Gavin

Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases Thumbnail


Authors

Sanaz Ahmadipour

Laura Beswick



Abstract

Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate biosynthesis. Enzymatic methods to access these key materials offer a powerful alternative to traditional chemical synthesis routes. Herein we review recent advances in the enzymatic pyrophosphorylation of glycosyl 1-phosphates for the provision of both native and modified sugar-nucleotides.

Journal Article Type Article
Acceptance Date Sep 10, 2018
Online Publication Date Sep 14, 2018
Publication Date 2018-11
Publicly Available Date May 26, 2023
Journal Carbohydrate Research
Print ISSN 0008-6215
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 469
Pages 38 - 47
DOI https://doi.org/10.1016/j.carres.2018.09.002
Keywords Sugar-nucleotide, Glycosyl-1-phosphate, Pyrophosphorylase, Enzymatic synthesis, Nucleotidylyltransferase
Publisher URL https://doi.org/10.1016/j.carres.2018.09.002

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