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The potential of magnetic hyperthermia for triggering the differentiation of cancer cells

Moise, Sandhya; Byrne, James M.; El Haj, Alicia J.; Telling, Neil D.

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Authors

Sandhya Moise

James M. Byrne

Alicia J. El Haj



Abstract

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro and in vivo, however little attention has been paid to the cellular functioning of the surviving cells. We report here new evidence demonstrating the onset of thermally triggered differentiation in osteosarcoma cancer cells that survive magnetic hyperthermia treatment. This raises the possibility that in addition to causing cell death, magnetic hyperthermia could induce surviving cancer cells to form more mature cell types and thereby inhibit their capacity to self-renew. Such processes could prove to be as important as cell death when considering magnetic hyperthermia for treating cancer.

Journal Article Type Article
Acceptance Date Oct 28, 2018
Publication Date Nov 28, 2018
Publicly Available Date Mar 28, 2024
Journal Nanoscale
Print ISSN 2040-3364
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 10
Issue 44
Pages 20519-20525
DOI https://doi.org/10.1039/c8nr05946b
Publisher URL http://doi.org/10.1039/c8nr05946b

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