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Jenkins, V, Solis-Trapala, I, Payne, H, Mason, M, Fallowfield, L, May, S, Matthews, L and Catt, S (2019) Treatment Experiences, Information Needs, Pain and Quality of Life in Men with Metastatic Castrate-resistant Prostate Cancer: Results from the EXTREQOL Study. Clinical Oncology, 31 (2). pp. 99-107. ISSN 0936-6555
EXTREQOLrevised manuscriptclean version 15th Oct.pdf - Accepted Version
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Abstract
Aims
Delaying progression, ameliorating symptoms and maintaining quality of life (QoL) are primary aims of treatment for metastatic castrate-resistant prostate cancer (mCRPC). Real-world rather than clinical trial data about symptoms and side-effects are sparse. In EXTREQOL, patients' QoL, pain and information needs were recorded during treatment.
Material and methods
Men with mCRPC from 20 UK cancer centres starting various systemic mCRPC treatments completed QoL, pain and information needs questionnaires at baseline, 3 and 6 months.
Results
In total, 132 patients were recruited. Overall QoL declined significantly by 6 months (Functional Assessment of Cancer Therapy-Prostate [FACT-P] mean = –3.89, 95% confidence interval –6.7 to –1.05, P = 0.007; Trial Outcome Index [TOI] analysis mean = –3.10, 95% confidence interval –5.34 to –0.83, P = 0.007). Those who came off novel therapy and remained on luteinising hormone-releasing hormone agonist therapy alone had worse scores than patients receiving concomitant chemotherapy (Prostate Concerns Subscale mean difference = –4.45, 95% confidence interval –7.06 to –1.83, P = 0.001; TOI mean difference = –5.62, 95% confidence interval –10.97 to –0.26, P = 0.040). At 3 and 6 months, men who reported pain at baseline improved (43%, 40%), but for others pain levels remained the same (45%, 42%) or worsened (13%, 18%). Information regarding supportive care was lacking throughout the period of time on the study.
Conclusion
Most mCRPC treated patients experience reduced QoL and inadequate pain control. More help with pain management and better information provision regarding supportive care is warranted.
Item Type: | Article |
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Additional Information: | This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://doi.org.10.1016/j.clon.2018.11.001 - please refer to any applicable terms of use of the publisher. |
Uncontrolled Keywords: | information needs; mCRPC; pain control; QoL; side-effects |
Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
Divisions: | Faculty of Medicine and Health Sciences > Primary Care Health Sciences |
Depositing User: | Symplectic |
Date Deposited: | 26 Nov 2018 12:43 |
Last Modified: | 23 Nov 2019 01:30 |
URI: | https://eprints.keele.ac.uk/id/eprint/5527 |