Farooq, S, Choudry, A, Cohen, D, Naeem, F and Ayub, M (2019) Barriers to using clozapine in treatment-resistant schizophrenia: systematic review. BJPsych Bulletin, 43 (1). pp. 8-16. ISSN 2056-4694

[thumbnail of S Farooq - Barrier to using clozapine.pdf]
S Farooq - Barrier to using clozapine.pdf - Published Version
Available under License Creative Commons Attribution.

Download (710kB) | Preview


Aims and method
To systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018. The following search terms were used: treatment-resistant schizophrenia, clozapine, barriers, use, prescription rates, implementation, clozaril and prescribing practices. Following a review of the literature, 15 papers were included in the review.

RESULTS: The major barriers that were identified included mandatory blood testing, fear of serious side-effects and lack of adherence by the patients, difficulty in identifying suitable patients, service fragmentation, and inadequate training in or exposure to using clozapine.

Clinical implications
In view of consistent evidence across the studies on inadequate knowledge and skills as a significant barrier, we suggest that a certification requiring competence in initiating and managing side-effects of clozapine becomes a mandatory requirement in training programmes.

Declarations of interest

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Cambridge University Press at http://doi.org/10.1192/bjb.2018.67 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Treatment resistant schizophrenia, barriers, clozapine
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 10 Dec 2018 15:25
Last Modified: 06 Feb 2019 10:28
URI: https://eprints.keele.ac.uk/id/eprint/5565

Actions (login required)

View Item
View Item