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X-ray diffraction from bone employing annular and semi-annular beams

Dicken, AJ; Evans, JPO; Rogers, KD; Stone, N; Greenwood, CE; Godber, SX; Prokopiou, D; Clement, JG; Lyburn, ID; Martin, RM; Zioupos, P

X-ray diffraction from bone employing annular and semi-annular beams Thumbnail


Authors

AJ Dicken

JPO Evans

KD Rogers

N Stone

SX Godber

D Prokopiou

JG Clement

ID Lyburn

RM Martin

P Zioupos



Abstract

There is a compelling need for accurate, low cost diagnostics to identify osteotissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as ‘bone quality’ need to exceed that provided currently by densitometry. Bone mineral chemistry and microstructure can be determined from coherent x-ray scatter signatures of bone specimens. Therefore, if these signatures can be measured, in vivo, to an appropriate accuracy it should be possible by extending terms within a fracture risk model to improve fracture risk prediction.
In this preliminary study we present an examination of a new x-ray diffraction technique that employs hollow annular and semi-annular beams to measure aspects of ‘bone quality’. We present diffractograms obtained with our approach from ex vivo bone specimens at Mo Ka and W Ka energies.
Primary data is parameterized to provide estimates of bone characteristics and to indicate the precision with which these can be determined.

Journal Article Type Article
Acceptance Date Jun 8, 2015
Publication Date Jul 10, 2015
Publicly Available Date Mar 29, 2024
Journal Physics in Medicine and Biology
Print ISSN 0031-9155
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 60
Issue 15
Pages 5803 - 5812
DOI https://doi.org/10.1088/0031-9155/60/15/5803
Keywords x-ray diffraction, diagnostics, osteoporosis, annular beam
Publisher URL https://iopscience.iop.org/article/10.1088/0031-9155/60/15/5803

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