Gianpiero Di Leva g.dileva@keele.ac.uk
Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
Di Leva
Authors
Abstract
An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53. Moreover, evaluating miR-205 expression in a panel of cell lines belonging to the highly aggressive triple negative breast cancer (TNBC) subtype, which still lacks an effective targeted therapy and characterized by an extremely undifferentiated and mesenchymal phenotype, we demonstrated that this microRNA is critically down-expressed compared to a normal-like cell line. Re-expression of miR-205 where absent strongly reduces cell proliferation, cell cycle progression and clonogenic potential in vitro, and inhibits tumor growth in vivo, and this tumor suppressor activity is at least partially exerted through targeting of E2F1, master regulator of cell cycle progression, and LAMC1, component of extracellular matrix involved in cell adhesion, proliferation and migration.
Acceptance Date | Mar 12, 2012 |
---|---|
Publication Date | Apr 19, 2012 |
Journal | Molecular Oncology |
Print ISSN | 1574-7891 |
Publisher | Wiley |
Pages | 458 - 472 |
DOI | https://doi.org/10.1016/j.molonc.2012.03.003 |
Keywords | miR-205; p53; E2F1; LAMC1 |
Publisher URL | https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.molonc.2012.03.003 |
Files
G Di Leva - Oncosupressive role of p53-induced....pdf
(1.8 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature.
(2023)
Journal Article
A KRAS-responsive long non-coding RNA controls microRNA processing
(2021)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search