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Mehdi, H, Gong, W, Guo, H, Watkinson, M, Ma, H, Wajahat, A and Ning, G (2017) Aggregation‐Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells. Chemistry: A European Journal, 23 (53). 13067 - 13075. ISSN 0947-6539

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Abstract

Two novel organic fluorophores, containing bis‐naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation‐induced emission (AIE) and a remarkable highly selective ratiometric fluorescence response towards Zn2+ in solution as well as in human liver cancer cells. The AIE behavior of this fluorophore was fully verified by fluorescence and UV/Vis spectroscopy, quantum yield calculations, and single‐crystal X‐ray diffraction, which revealed an intricate crystal packing system. Conversely, a fluorophore that lacks the isobutylene moiety did not exhibit any significant fluorescent properties as a result of its more flexible molecular structure that presumably allows free intramolecular rotational processes to occur.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Wiley at https://doi.org/10.1002/chem.201701948 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: aggregation-induced emission, bioimaging, flurophores, sensors, zinc
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Depositing User: Symplectic
Date Deposited: 03 Jun 2019 14:40
Last Modified: 03 Jun 2019 14:43
URI: https://eprints.keele.ac.uk/id/eprint/6436

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