Dr. Dahai Yu d.yu@keele.ac.uk
Optimal cut-off threshold in pulse pressure predicting cardiovascular death among newly diagnosed end-stage renal disease patients: A prospective cohort study.
Yu
Authors
Abstract
Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage renal disease (ESRD) treated by dialysis. Pulse pressure (PP) as an independent prognostic factor of cardiovascular risk might be clinically implicated in predicting the short-term deaths due to cardiovascular diseases in ESRD patients. This study aimed to investigate the dose-response association between pulse pressure (PP) and risk of cardiovascular mortality in patients initialising peritoneal dialysis (PD). All patients registered with the Henan Peritoneal Dialysis Registry (HPDR) between 2007 and 2014 were incorporated in the current cohort study. PP was assessed by the date of initialisation of PD and cardiovascular mortality in 2 years after the initialisation of PD was defined as the outcome. All accessible clinical measurements were screened as covariables. Further dose–response relationships between PP and risks were explored using spline models. There was a non-linear relationship between PP and the risk of 2-year death for a cardiovascular diseases (P < 0.001 for linearity test). The PP associated with the lowest risk of cardiovascular mortality was 61 (95% CI 56–64) mmHg. In ESRD patients initialising PD, PP is a good prognostic factor of risk of short-term cardiovascular mortality. The risk is lowest with a PP of 56–64 mmHg
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 1, 2019 |
Online Publication Date | Jul 5, 2019 |
Publication Date | 2019-07 |
Publicly Available Date | Mar 28, 2024 |
Journal | Medicine |
Print ISSN | 0025-7974 |
Publisher | Lippincott, Williams & Wilkins |
Peer Reviewed | Peer Reviewed |
Volume | 98 |
Issue | 27 |
Article Number | e16340 |
DOI | https://doi.org/10.1097/MD.0000000000016340 |
Keywords | cardiovascular diseases, dose-response relationship, mortality, peritoneal dialysis, pulse pressure |
Publisher URL | https://journals.lww.com/md-journal/fulltext/2019/07050/Optimal_cut_off_threshold_in_pulse_pressure.102.aspx#pdf-link |
PMID | 31277187 |
Files
Manuscript PP and CVD death in PD final 2019.pdf
(472 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Where does it hurt? Small area estimates and inequality in the prevalence of chronic pain
(2023)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search