Skip to main content

Research Repository

Advanced Search

Optimal cut-off threshold in pulse pressure predicting cardiovascular death among newly diagnosed end-stage renal disease patients: A prospective cohort study.

Yu

Optimal cut-off threshold in pulse pressure predicting cardiovascular death among newly diagnosed end-stage renal disease patients: A prospective cohort study. Thumbnail


Authors



Abstract

Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage renal disease (ESRD) treated by dialysis. Pulse pressure (PP) as an independent prognostic factor of cardiovascular risk might be clinically implicated in predicting the short-term deaths due to cardiovascular diseases in ESRD patients. This study aimed to investigate the dose-response association between pulse pressure (PP) and risk of cardiovascular mortality in patients initialising peritoneal dialysis (PD). All patients registered with the Henan Peritoneal Dialysis Registry (HPDR) between 2007 and 2014 were incorporated in the current cohort study. PP was assessed by the date of initialisation of PD and cardiovascular mortality in 2 years after the initialisation of PD was defined as the outcome. All accessible clinical measurements were screened as covariables. Further dose–response relationships between PP and risks were explored using spline models. There was a non-linear relationship between PP and the risk of 2-year death for a cardiovascular diseases (P < 0.001 for linearity test). The PP associated with the lowest risk of cardiovascular mortality was 61 (95% CI 56–64) mmHg. In ESRD patients initialising PD, PP is a good prognostic factor of risk of short-term cardiovascular mortality. The risk is lowest with a PP of 56–64 mmHg

Journal Article Type Article
Acceptance Date Jul 1, 2019
Online Publication Date Jul 5, 2019
Publication Date 2019-07
Publicly Available Date Mar 28, 2024
Journal Medicine
Print ISSN 0025-7974
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 98
Issue 27
Article Number e16340
DOI https://doi.org/10.1097/MD.0000000000016340
Keywords cardiovascular diseases, dose-response relationship, mortality, peritoneal dialysis, pulse pressure
Publisher URL https://journals.lww.com/md-journal/fulltext/2019/07050/Optimal_cut_off_threshold_in_pulse_pressure.102.aspx#pdf-link
PMID 31277187

Files




You might also like



Downloadable Citations