Keele Research Repository

Characteristics and outcomes of patients with lymphoma undergoing PCI are unknown. Therefore, we analyzed clinical characteristics and outcomes in patients that underwent percutaneous coronary intervention (PCI) and had a concomitant diagnosis of Hodgkin’s (HL) or non-Hodgkin’s (NHL) lymphoma. We analyzed patients with and without lymphoma diagnosis from the Nationwide Inpatient Sample in the US who underwent PCI procedure during 2004-2014. Multivariable regression analysis was performed to examine the association between lymphoma diagnosis and clinical outcomes post-PCI including shortterm complications and in-hospital mortality. A total of 7,119,539 PCI procedures were included in the analysis and 18,052 patients had a diagnosis of lymphoma (0.25%). These patients were likely to experience in-hospital mortality (OR 1.39, 95%CI 1.25-1.54), stroke or transient ischemic attack (TIA) (OR 1.75, 95%CI 1.61-1.90), and any in-hospital complication (OR 1.31, 95%CI 1.25-1.37), following PCI. In the lymphoma subtypeanalysis, diagnosis of HL was associated with an increased odds of in-hospital death (OR 1.40, 95% CI 1.24-1.56), any in-hospital complication (OR 1.31, 95% CI 1.25-1.38), bleeding complications (OR 1.12 95% CI 1.05-1.20) and vascular complications (OR 1.13 95%CI 1.06-1.20) while these odds were not significantly associated with NHL diagnosis. Finally, both types of lymphoma were associated with an increased odds of stroke/TIA following PCI (OR 1.82, 95% CI 1.67-1.99 and OR 1.31, 95% CI 1.05-1.63, respectively). In conclusion, while the prevalence of lymphoma in the observed PCI cohort was low, a diagnosis of lymphoma was associated with an adverse prognosis following PCI, primarily in patients with the HL diagnosis.