Francis Gilchrist f.j.gilchrist@keele.ac.uk
Factors affecting the growth of infants diagnosed with cystic fibrosis by newborn screening
Gilchrist; Kyriacou
Abstract
Newborn screening (NBS) for cystic fibrosis (CF) improves nutritional outcomes. Despite early dietetic intervention some children fail to grow optimally. We report growth from birth to 2 years in a cohort of children diagnosed with CF by NBS and identify the variables that influence future growth.
Methods
One hundred forty-four children were diagnosed with CF by the West Midlands Regional NBS laboratory between November 2007 and October 2014. All anthropometric measurements and microbiology results from the first 2 years were collated as was demographic and CF screening data. Classification modelling was used to identify the key variables in determining future growth.
Results
Complete data were available on 129 children. 113 (88%) were pancreatic insufficient (PI) and 16 (12%) pancreatic sufficient (PS). Mean birth weight (z score) was 3.17?kg (-?0.32). There was no significant difference in birth weight (z score) between PI and PS babies: 3.15?kg (-?0.36) vs 3.28?kg (-?0.05); p?=?0.33. By the first clinic visit the difference was significant: 3.42?kg (-?1.39) vs 4.60?kg (-?0.48); p?<?0.0001. Weight and height remained lower in PI infants in the first year of life. In the first 2 years of life, 18 (14%) infants failed to regain their birth weight z score. The median time to achieve a weight z score of -?2, -?1 and 0 was 18, 33 and 65?weeks respectively. The median times to reach the same z scores for height were 30, 51 and 90?weeks. Birth weight z score, change in weight z score from birth to first clinic, faecal elastase, isolation of Pseudomonas aeruginosa, isolation of Staphylococcus aureus and sweat chloride were the variables identified by the classification models to predict weight and height in the first and second year of life.
Conclusions
Babies with CF have a lower birth weight than the healthy population. For those diagnosed with CF by NBS, the weight difference between PI and PS babies was not significantly different at birth but became so by the first clinic visit. The presence of certain factors, most already identifiable at the first clinic visit can be used to identify infant at increased risk of poor growth.
Acceptance Date | Sep 16, 2019 |
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Publication Date | Oct 15, 2019 |
Publicly Available Date | Mar 28, 2024 |
Journal | BMC Pediatrics |
Publisher | Springer Verlag |
DOI | https://doi.org/10.1186/s12887-019-1727-9 |
Keywords | infants; cystic fibrosis; newborn; screening |
Publisher URL | https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-019-1727-9#Abs1 |
Files
patterson_etal.pdf
(751 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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