Bharadwaj, A, Potts, J, Mohamed, MO, Parwani, P, Swamy, P, Lopez-Mattei, JC, Rashid, M, Kwok, CS, Fischman, DL, Vassiliou, VS, Freeman, P, Michos, E and Mamas, M (2020) Acute myocardial infarction, treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the United States. European Heart Journal, 41 (23). pp. 2183-2193. ISSN 0195-668X

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The aim of this study is to evaluate temporal trends, treatment and clinical outcomes of patients who present with an acute myocardial infarction (AMI) and have a current or historical diagnosis of cancer, according to cancer type and presence of metastases.

Methods and Results:
Data from 6,563,255 patients presenting with an AMI between 2004-2014 from the US National Inpatient Sample (NIS) database were analysed. A total of 5,966,955 had no cancer, 186,604 had current cancer and 409,697 had a historical diagnosis of cancer. Prostate, breast, colon and lung cancer were the four most common types of cancer. Patients with cancer were older with more comorbidities. Differences in invasive treatment were noted, 43.9% received percutaneous coronary intervention (PCI) in patients without cancer whilst only 21.0% of patients with lung cancer received PCI. Lung cancer was associated with the highest in-hospital mortality (odds ratio (OR) 2.71 95% confidence interval (CI) 2.62,2.80), major adverse cardiovascular and cerebrovascular complications (OR 2.38 95% CI 2.31,2.45) and stroke (OR 1.91 95% CI 1.80,2.02), while colon cancer was associated with highest risk of bleeding (OR 2.82 95% CI 2.68,2.98). Irrespective of the type of cancer, presence of metastasis was associated with worse in-hospital outcomes, and historical cancer did not adversely impact on survival (OR 0.90, 95% CI 0.89,0.91).

A concomitant cancer diagnosis is associated with a conservative medical management strategy for AMI, and worse clinical outcomes, compared to patients without cancer. Survival and clinical outcomes in the context of AMI vary significantly according to the type of cancer and metastasis status. The management of this high-risk group is challenging and requires a multidisciplinary and patient-centred approach to improve their outcomes.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) will be available online via Oxford University Press at - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: AMI, Cancer, Complications, Mortality, myocardial infarction, acute, cerebrovascular accident, ischemic stroke, cancer, comorbidity, hospital mortality, neoplasm, metastasis, mortality, treatment outcome, lung cancer, colon cancer, cancer diagnosis
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 18 Nov 2019 13:51
Last Modified: 04 Dec 2020 01:30

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