D Simmons
The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study
Simmons, D; Shang, J; Yu, D; Cai, Y; Wang, Z; Zhao, B; Zhao, Z
Abstract
Insulin resistance is usually a key factor in the development of type 2 diabetes. The triglyceride glucose (TyG) index is a marker of insulin resistance which is also implicated in the risk of nephropathy among people with type 2 diabetes. This study aimed to examine associations and potential thresholds between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes. A nested case–control study incorporating 950 incident biopsy-proven diabetic nephropathy cases and age, gender matched 4750 patients with treated type 2 diabetes as controls selected by risk-set sampling method was implemented. The dose–response association between TyG index with subsequent risk of newly diagnosed biopsy-proven diabetic nephropathy after adjustment for age, gender, blood pressure, and other major cardiovascular risk factors were examined by conditional logistic regression model. A non-linear relationship was identified between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy with a potential threshold of TyG at 9.05–9.09. Similar relationships with the same threshold were also found in the analyses by fasting glucose and triglyceride levels. TyG index might be a prognostic factor in predicting newly development of biopsy-proven diabetic nephropathy among patients with treated type 2 diabetes. In people with type 2 diabetes, TyG index above 9.05–9.09 could be a prognostic threshold to identify individuals at high risk of diabetic nephropathy. Further replication studies are warranted.
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 18, 2019 |
Publication Date | Nov 14, 2019 |
Publicly Available Date | Mar 29, 2024 |
Journal | Medicine |
Print ISSN | 0025-7974 |
Electronic ISSN | 1536-5964 |
Publisher | Lippincott, Williams & Wilkins |
Peer Reviewed | Peer Reviewed |
Volume | 98 |
Issue | 46 |
Article Number | e17995 |
Pages | 1-7 |
DOI | https://doi.org/10.1097/md.0000000000017995 |
Keywords | diabetes, diabetic retinopathy, insulin resistance, prognosis, TyG index |
Publisher URL | http://doi.org/10.1097/MD.0000000000017995 |
PMID | 31725665 |
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