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The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study

Simmons, D; Shang, J; Yu, D; Cai, Y; Wang, Z; Zhao, B; Zhao, Z

The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study Thumbnail


Authors

D Simmons

J Shang

Y Cai

Z Wang

B Zhao

Z Zhao



Abstract

Insulin resistance is usually a key factor in the development of type 2 diabetes. The triglyceride glucose (TyG) index is a marker of insulin resistance which is also implicated in the risk of nephropathy among people with type 2 diabetes. This study aimed to examine associations and potential thresholds between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes. A nested case–control study incorporating 950 incident biopsy-proven diabetic nephropathy cases and age, gender matched 4750 patients with treated type 2 diabetes as controls selected by risk-set sampling method was implemented. The dose–response association between TyG index with subsequent risk of newly diagnosed biopsy-proven diabetic nephropathy after adjustment for age, gender, blood pressure, and other major cardiovascular risk factors were examined by conditional logistic regression model. A non-linear relationship was identified between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy with a potential threshold of TyG at 9.05–9.09. Similar relationships with the same threshold were also found in the analyses by fasting glucose and triglyceride levels. TyG index might be a prognostic factor in predicting newly development of biopsy-proven diabetic nephropathy among patients with treated type 2 diabetes. In people with type 2 diabetes, TyG index above 9.05–9.09 could be a prognostic threshold to identify individuals at high risk of diabetic nephropathy. Further replication studies are warranted.

Journal Article Type Article
Acceptance Date Oct 18, 2019
Publication Date Nov 14, 2019
Publicly Available Date Mar 29, 2024
Journal Medicine
Print ISSN 0025-7974
Electronic ISSN 1536-5964
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 98
Issue 46
Article Number e17995
Pages 1-7
DOI https://doi.org/10.1097/md.0000000000017995
Keywords diabetes, diabetic retinopathy, insulin resistance, prognosis, TyG index
Publisher URL http://doi.org/10.1097/MD.0000000000017995
PMID 31725665

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