Keele Research Repository
Explore the Repository
Hammond, AM and Galizi, R (2018) Gene drives to fight malaria: current state and future directions. Pathogens and Global Health, 111 (8). 412 - 423. ISSN 2047-7732
Gene drives to fight malaria current state and future directions.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (2MB) | Preview
Abstract
Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate cost-effective interventions that benefit society without obvious bias related to wealth, age or education. Their species-specific design offers the potential to reduce environmental risks and aim to be compatible and complementary with other control strategies, potentially expediting the elimination and eradication of malaria. A number of strategies have been proposed for gene-drive based control of the malaria mosquito and recent demonstrations have shown proof-of-principle in the laboratory. Though several technical, ethical and regulatory challenges remain, none appear insurmountable if research continues in a step-wise and open manner.
Item Type: | Article |
---|---|
Additional Information: | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
Uncontrolled Keywords: | Gene, Malaria, Directions |
Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
Divisions: | Faculty of Natural Sciences > School of Life Sciences |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 16 Jan 2020 09:08 |
Last Modified: | 16 Jan 2020 09:08 |
URI: | https://eprints.keele.ac.uk/id/eprint/7501 |