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Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents.

Reynisson

Authors



Abstract

Phosphatidylcholine-specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits from four different structural series that contain the molecular scaffold of benzenesulphonamides (10), pyrido[3,4-b]indoles (22), morpholinobenzoic acid (84) and benzamidobenzoic acid (80). 164 structural analogues were tested to investigate the chemical space around the hit series and to generate preliminary structurally activity relationships (SAR). Two of the pyrido[3,4-b]indoles (22_10 and 22_15) had comparable or better potency as D609, an established but non-drug-like PC-PLC inhibitor. Furthermore, three morpholinobenzoic acids (84, 84_4 and 84_5) had superior potency than D609. Therefore, this study paves the way towards the development of drug-like PL-PLC inhibitors as potential anticancer agents.

Acceptance Date Nov 26, 2019
Publication Date Nov 27, 2019
Publicly Available Date Mar 28, 2024
Journal European Journal of Medicinal Chemistry
Print ISSN 0223-5234
Publisher Elsevier
Pages 111919 - ?
DOI https://doi.org/10.1016/j.ejmech.2019.111919
Keywords phosphatidylcholine-specific phospholipase C, drug-like, inhibitors, anticancer, agents
Publisher URL https://www.sciencedirect.com/science/article/pii/S0223523419310712?via%3Dihub