Keele Research Repository

I
codextrin (ICO) has been a major addition to the management of ultrafiltration (UF) in peritoneal dialysis
(PD), allowing sustained UF during long dwells and maintenance of UF in the face of increased membrane solute transport, while minimizing the deleterious effects of local and systemic glucose exposure. Initial studies indicated ICO typically achieved UF over 500 mL (1–4), but these studies were mostly using the overnight dwell of continuous ambulatory PD and may not always have
taken overfill into account. An increasing number of studies are reporting greater variation in achieved UF, particularly in automated PD patients that use a longer dwell (3–5). This runs counter to the UF with ICO previously predicted by computer-generated three-pore modeling, which suggested UF should increase linearly up to at least 17 hours. Given the importance of UF and the widespread use of ICO, this is an area requiring further clarification.