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Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage.

Forrester-Soto

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Thumbnail


Authors

Forrester-Soto



Abstract

Previous imported cases of Lassa fever (LF) into the United Kingdom from the Ivory Coast and Mali, as well as the detection of Lassa virus (LASV) among the Mastomys natalensis population within Mali has led to the suggestion that the endemic area for LF is expanding. Initial phylogenetic analyses arrange isolates from Mali and the Ivory Coast separately from the classical lineage IV isolates taken from Sierra Leone, Guinea, and Liberia. The availability of full genome sequences continues to increase, allowing for a more complete phylogenetic comparison of the isolates from Mali and the Ivory Coast to the other existing isolates. In this study, we utilized a Bayesian approach to infer the demographic histories of each LASV isolate for which the full sequence was available. Our results indicate that the isolates from Mali and the Ivory Coast group separately from the isolates of lineage IV, comprising a distinct fifth lineage. The split between lineages IV and V is estimated to have occurred around 200-300 years ago, which coincides with the colonial period of West Africa.

Acceptance Date Oct 4, 2015
Publication Date Oct 24, 2015
Publicly Available Date Mar 29, 2024
Journal Frontiers in Microbiology
Publisher Frontiers Media
Pages 1037 - 1037
DOI https://doi.org/10.3389/fmicb.2015.01037
Keywords lassa virus, Mali, Ivory Coast, lineage.
Publisher URL https://doi.org/10.3389/fmicb.2015.01037

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