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Rescue of long-term memory after reconsolidation blockade

Trent, Simon; Barnes, Philip; Hall, Jeremy; Thomas, Kerrie L.

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Authors

Philip Barnes

Jeremy Hall

Kerrie L. Thomas



Abstract

Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdown of either Zif268 or Arc levels in the brain, and inhibition of protein synthesis, after a brief recall results in a non-recoverable retrograde amnesia, known as reconsolidation blockade. These experimental manipulations are seen as key proof for the existence of reconsolidation. However, here we demonstrate that despite disrupting the molecular correlates of reconsolidation in the hippocampus, rodents are still able to recover contextual memories. Our results challenge the view that reconsolidation is a separate memory process and instead suggest that the molecular events activated initially at recall act to constrain premature extinction.

Journal Article Type Article
Acceptance Date Jun 24, 2015
Publication Date Aug 4, 2015
Publicly Available Date Mar 29, 2024
Journal Nature Communications
Print ISSN 2041-1723
Peer Reviewed Peer Reviewed
Volume 4
Article Number 7897
DOI https://doi.org/10.1038/ncomms8897
Keywords long-term memory, reconsolidation blockade.
Publisher URL https://www.nature.com/articles/ncomms8897#article-info

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