Mamas Mamas m.mamas@keele.ac.uk
Prevalence and in-hospital outcomes of patients with malignancies undergoing de novo cardiac electronic device implantation in the United States
Mamas
Authors
Abstract
Aims: To study the outcomes of cancer patients undergoing cardiac implantable electronic device (CIED) implantation.
Methods: De novo CIED implantations (2004 to 2015; n=2,670,590) from the National Inpatient Sample were analysed for characteristics and in-hospital outcomes, stratified by presence of cancer (no cancer, historical and current cancers) and further by current cancer type (haematological, lung, breast, colon and prostate).
Results: Current and historical cancer prevalence has increased from 3.3% to 7.8%, and 5.8% to 7.8%, respectively between 2004 to 2015. Current cancer was associated with increased adjusted odd ratios (OR) of MACE (composite of all-cause mortality, thoracic and cardiac complications, and device-related infection; OR 1.26, 95% confidence interval (CI) 1.23,1.30), all-cause mortality (OR 1.43, 95%CI 1.35,1.50), major bleeding (OR 1.38, 95%CI 1.32,1.44) and thoracic complications (OR 1.39, 95%CI 1.35,1.43). Differences in outcomes were observed according to cancer type, with significantly worse MACE, mortality and thoracic complications with lung and haematological malignancies, and increased major bleeding in colon and prostate malignancies. The risk of complications was also different according to CIED subtype.
Conclusion: The prevalence of cancer patients amongst those undergoing CIED implantation has significantly increased over 12 years. Overall, current cancers are associated with increased mortality and worse outcomes, especially in patients with lung, haematological and colon malignancies whereas there was no evidence that historical cancer had a negative impact on outcomes.
Acceptance Date | Mar 26, 2020 |
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Publication Date | May 3, 2020 |
Publicly Available Date | Mar 28, 2024 |
Journal | EP-Europace |
Print ISSN | 1099-5129 |
Publisher | Oxford University Press |
Pages | 1083-1096 |
DOI | https://doi.org/10.1093/europace/euaa087 |
Keywords | Cardiac devices, pacemakers, defibrillator, cardiac resynchronization, cancer, malignancy, outcomes |
Publisher URL | https://doi.org/10.1093/europace/euaa087 |
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CIED cancer paper Final Europace.docx
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
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